Compelling Clinical Data

Collection of clinical evidence and scientific literature supporting ReActiv8 Restorative Neurostimulation

Clinical Study Publications –
First ever randomized sham-controlled research in neuromodulation

ReActiv8 – B Trial for FDA Approval

ReActiv8 – A Trial for CE Mark

Real World Evidence

Restorative neurostimulation for chronic mechanical low back pain: results from a prospective multi-centre longitudinal cohort Mainstay Medical Australia


  • 57% of patients experienced a substantial improvement of ≥ 50% reduction in NRS pain score
  • 51% of patients experienced a substantial improvement of ≥ 15-point reduction in ODI score
  • Excellent safety profile compared to similarly implanted devices

Restorative Neurostimulation –
Literature and scientific discussions on the importance of this new therapy

Physiologic Testing –
How to objectively identify patients with neuromotor dysfunction

Clinical observation of standing trunk movements: what do the aberrant movement patterns tell us Mainstay Medical Australia


  • Observation of trunk movement is considered an important part of the clinical examination of patients with low back pain (LBP).
  • The presence of forward-bending movement aberrance is frequently seen in patients with acute/subacute, nonspecific LBP, compared to those without a history of LBP.
  • Aberrant movements indicate that some motor control or musculoskeletal impairment remains unresolved in this group.

Role of the multifidus – how recent science has identified
this muscle as critical in preventing CLBP

the role of the lumbar multifidus in chronic low back pain: A review Mainstay Medical Australia


  • The Multifidus morphology is uniquely different from other lumbar muscles, and therefore has a special role in lumbar stability.  
  • Changes in the multifidus have been found by many studies to be related to low back pain.
  • Injury and overloading of lumbar tissues has been shown to cause multifidus inhibition. 
  • Clinical studies have demonstrated that the multifidus can be rehabilitated and low back pain decreased.
The stabilizing system of the spine Part 1 Function, dysfunction, adaption, and enhancement Mainstay Medical Australia


  • The spinal stabilizing system consists of three subsystems:
    • the passive spinal column subsystem, 
    • the active muscular subsystem,
    • the neural and feedback control subsystem. 
  • Injury, degeneration or disease can cause dysfunction in the spinal system, which cannot be compensated for beyond certain limits. 
The stabilizing system of the spine part 2 neutral zone and instability hypothesis Mainstay Medical Australia


  • The neutral zone is the spinal range of motion where there is little to no resistance. 
  • An increase in the size of the neutral zone is correlated with spinal degeneration and injury.
  • The bodies’ inability to maintain neutral zones within physiological limits, therefore causing mechanical dysfunction and pain, is termed “clinical instability”.  
  • Improved neurocontrol and motor function may reduce an aberrant neutral zone, decreasing clinical instability and reducing pain. 
Clinical spinal instability and low back pain Mainstay Medical Australia


  • Increased neutral zones as a result of injury or degeneration are shown to be correlated to pain. 
  • The spinal muscles provide significant stability to the spine.
  • Less efficient muscular control and decreased stability has been found in patients with low back pain. 
  • A compromised spinal system can be stabilized with muscle strengthening and retraining of the neuromuscular control system. 

Society Guidelines and Support

Healthcare Economics